N-cap helix nucleation： methods and their applications

Recapitulation of well-defined α-helices could result in constrained peptide mimetics with preferable secondary structures and enhanced therapeutic properties for various purposes. Among the helix-stabilizing strategies, the nucleation strategies are able to maximize recognition specificity of the o...

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Bibliographic Details
Published in:Science China. Chemistry 2017-06, Vol.60 (6), p.689-700
Main Authors: Wang, Dongyuan, Qin, Xuan, Zhao, Hui, Li, Zigang
Format: Article
Language:English
Subjects:
Amino acids
Chemical bonds
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Helices
Hydrogen bonds
Mini Reviews
Nucleation
Peptides
Propagation
Proteins
Recognition
二级结构
分子识别
应用
形核
成核
构造策略
模拟肽
螺旋
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Summary:Recapitulation of well-defined α-helices could result in constrained peptide mimetics with preferable secondary structures and enhanced therapeutic properties for various purposes. Among the helix-stabilizing strategies, the nucleation strategies are able to maximize recognition specificity of the original sequence without compromising the molecular recognition surface. In this review,current methodologies of helix nucleation are introduced including their constructing strategies, structure features and proof of concept biological applications.
ISSN:1674-7291
1869-1870
DOI:10.1007/s11426-016-9033-y