Nanoelectrochemical architectures for high-spatial-resolution single cell analysis

The analysis of single cells instead of cell populations is important for characterizing cellular heterogeneity and elucidating the cellular signalling pathways. Nanoelectrodes have emerged as an increasingly important tool for biomolecule analyses at the single-cell level with high spatial or tempo...

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Bibliographic Details
Published in:Science China. Chemistry 2017-10, Vol.60 (10), p.1277-1284
Main Authors: Zhou, Junyu, Jiang, Dechen, Chen, Hong-Yuan
Format: Article
Language:English
Subjects:
Biomolecules
Cell cycle
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Electrical measurement
Electrodes
Electrons
Heterogeneity
Lasers
Microscopy
Reviews
Spatial resolution
Temporal resolution
Voltammetry
单细胞分析
扫描电化学显微镜
时间分辨率
电化学体系
电化学方法
纳米生物
高分辨率
高空间分辨率
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Summary:The analysis of single cells instead of cell populations is important for characterizing cellular heterogeneity and elucidating the cellular signalling pathways. Nanoelectrodes have emerged as an increasingly important tool for biomolecule analyses at the single-cell level with high spatial or temporal resolution. Various electrochemical methods, such as amperometry and scanning electrochemical microscopy（SECM）, have been applied. Research to date has focused on the development of new nanoelectrochemical architectures, such as arrays, to achieve higher spatial resolution and faster analysis rates for single-cell analysis. In this review, the fabrication of these new nanoelectrochemical architectures and their applications in high spatial resolution single-cell analyses are discussed. The recent progress of Chinese researchers is highlighted.
ISSN:1674-7291
1869-1870
DOI:10.1007/s11426-017-9109-7