Caffeine improves exercise recuperation by cardiovascular and biochemical response in diabetic rats

• Published in: Sport sciences for health 2018-08, Vol.14 (2), p.371-377
• Main Authors: da Silva, Luiz Augusto, Weber, Vinicius Muller Reis, Wouk, Jéssica, Malfatti, Carlos Ricardo Maneck, Osiecki, Raul
• Format: Article
• Language: English
• Subjects: Animals; Blood pressure; Caffeine; Diabetes; Exercise; Fatty acids; Glucose; Glycerol; Heart rate; Homeostasis; Human Physiology; Humidity; Kinases; Medicine; Medicine & Public Health; Metabolic Diseases; Muscle contraction; Original Article; Phosphorylation; Sports Medicine
• ISSN: 1824-7490; 1825-1234
• DOI: 10.1007/s11332-018-0445-2

Objective The objective of this study was to evaluate caffeine effects on cardiovascular and biochemical parameters during the recovering time of aerobic exercise in diabetic rats. Materials and methods 24 animals of 60 days were allocated to four experimental groups: Control, Diabetic, Caffeine, and Diabetes + Caffeine. Diabetes mellitus was induced by an intraperitoneal administration of 60 mg/kg of alloxan. Once a day for 30 days, animals underwent training of forced swimming for 40 min and tied to loads of 4% of their body weight. On the 1st and 30th days of training, animals underwent a stress test, in which they performed 60 min of forced swimming with loads of 6% session of 6% of their body’s weight. Caffeine was administrated 30 min before the exercise at the test days. Cardiovascular responses such as systolic blood pressure (SBP), heart rate (HR), and double product (DP) were recorded before and after the tests. In addition, blood samples were collected for glucose, glycerol, and lactate analyses, by caudal puncture. Results Glucose values were lower in rats of group caffeine + diabetes when compared to animals of other groups (25%; p