Recent advances in radical-mediated fluorination through C-H and C-C bond cleavage

The C-H and C-C bonds are abundant in organic compounds,yet generally inert in chemical transformations.Therefore,direct functionalization of inert chemical bonds remains challenging.The fluorine-containing compounds are of special interest for their uses in medicinal chemistry.Direct fluorination o...

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Published in:Science China. Chemistry 2017-02, Vol.60 (2), p.214-222
Main Authors: Yan, Hong, Zhu, Chen
Format: Article
Language:English
Subjects:
Acids
Alkanes
C-C键
Carboxylic acids
Chemical bonds
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Copper
Covalent bonds
Fluorides
Fluorination
Fluorine
Organic compounds
Radicals
Reviews
Ring opening
介导
化学键
含氟化合物
断裂
有机化合物
氟化反应
自由基
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description The C-H and C-C bonds are abundant in organic compounds,yet generally inert in chemical transformations.Therefore,direct functionalization of inert chemical bonds remains challenging.The fluorine-containing compounds are of special interest for their uses in medicinal chemistry.Direct fluorination of C-H and C-C bonds undoubtedly represents one of the most ideal and attractive approaches to incorporate fluorine atom into complex molecules.Herein,we summarize the recent advances in radical-mediated C-H and C-C bond fluorination.Three types of transformations are discussed：（1）direct C-H abstraction/fluorination of alkanes;（2）decarboxylative fluorination of alkyl carboxylic acids;（3）ring-opening fluorination.
doi_str_mv 10.1007/s11426-016-0399-5
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subjects Acids
Alkanes
C-C键
Carboxylic acids
Chemical bonds
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Copper
Covalent bonds
Fluorides
Fluorination
Fluorine
Organic compounds
Radicals
Reviews
Ring opening
介导
化学键
含氟化合物
断裂
有机化合物
氟化反应
自由基
title Recent advances in radical-mediated fluorination through C-H and C-C bond cleavage
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