Detection of protein microarrays by oblique-incidence reflectivity difference technique

Biological microarrays with different proteins and different protein concentrations are detected without external labeling by an oblique-incidence reflectivity difference (OIRD) technique. The initial experiment results reveal that the intensities of OIRD signals can distinguish the different protei...

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Bibliographic Details
Published in:Science China. Physics, mechanics & astronomy mechanics & astronomy, 2010-02, Vol.53 (2), p.306-309
Main Authors: Wen, Juan, Lu, Heng, Wang, Xu, Yuan, Kun, Lü, HuiBin, Zhou, YueLiang, Yin, KuiJuan, Yang, GuoZhen, Li, Wei, Ruan, KangCheng
Format: Article
Language:English
Subjects:
Astronomy
Classical and Continuum Physics
Labels
Observations and Techniques
Physics
Physics and Astronomy
Proteins
Reflectance
Research Paper
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Summary:Biological microarrays with different proteins and different protein concentrations are detected without external labeling by an oblique-incidence reflectivity difference (OIRD) technique. The initial experiment results reveal that the intensities of OIRD signals can distinguish the different proteins and concentrations of protein. The OIRD technique promises feasible applications to life sciences for label-free and high-throughput detection.
ISSN:1674-7348
1869-1927
DOI:10.1007/s11433-010-0126-x