Simultaneous double thymic carcinoids: a rare initial manifestation of multiple endocrine neoplasia type 1

A 53-year-old man was referred to our hospital for treatment of two anterior mediastinal tumors. The anterior mediastinal tumors were resected by thymectomy under the probable diagnosis of double thymomas. The final pathological diagnosis was multiple thymic carcinoids. Although 20%–25% of patients...

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Bibliographic Details
Published in:General thoracic and cardiovascular surgery 2011-01, Vol.59 (1), p.68-72
Main Authors: Kikuchi, Ryutaro, Mino, Nobuya, Okamoto, Taku, Matsukura, Tadashi, Hirai, Takashi
Format: Article
Language:English
Subjects:
Biopsy
Carcinoid Tumor - diagnosis
Carcinoid Tumor - genetics
Carcinoid Tumor - pathology
Carcinoid Tumor - surgery
Cardiac Surgery
Cardiology
Case Report
Delayed Diagnosis
DNA Mutational Analysis
Humans
Male
Medicine
Medicine & Public Health
Middle Aged
Multiple Endocrine Neoplasia Type 1 - diagnosis
Multiple Endocrine Neoplasia Type 1 - genetics
Multiple Endocrine Neoplasia Type 1 - pathology
Multiple Endocrine Neoplasia Type 1 - surgery
Mutation
Neuroendocrine tumors
Pancreatic Neoplasms - diagnosis
Parathyroid Neoplasms - diagnosis
Predictive Value of Tests
Proto-Oncogene Proteins - genetics
Radiotherapy, Adjuvant
Surgical Oncology
Thoracic Surgery
Thymectomy
Thymus Neoplasms - diagnosis
Thymus Neoplasms - genetics
Thymus Neoplasms - pathology
Thymus Neoplasms - surgery
Tomography, X-Ray Computed
Treatment Outcome
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Summary:A 53-year-old man was referred to our hospital for treatment of two anterior mediastinal tumors. The anterior mediastinal tumors were resected by thymectomy under the probable diagnosis of double thymomas. The final pathological diagnosis was multiple thymic carcinoids. Although 20%–25% of patients with thymic carcinoid have a family history of multiple endocrine neoplasia type 1 (MEN-1), radiographic screening just after the operation did not detect any endocrine tumors. However, the patient had a urinary calculus 4 months 7 months after the operation. Endocrinological examination then revealed mild hypercalcemia, hypophosphatemia, hyperinsulinemia, and hyperprolactinemia. Radiologically, a parathyroid tumor and a pancreatic tumor were found. The patient was referred to a university hospital and a mutation of MEN-1 gene was detected. The diagnosis of MEN-1 was confirmed about 1 year after the operation.
ISSN:1863-6705
1863-6713
DOI:10.1007/s11748-010-0606-y