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Experimental Study of the Effectiveness of Naphazoline and Co-Administration of Filgrastim in Combined Radiation Injury

The effects of the drugs naphazoline and filgrastim, upon individual and co-administration, on the course and outcome of combined radiation–mechanical injury were examined in experimental studies in mice. In mice exposed to ionizing radiation at LD 50/30 with a subsequent mechanical injury, naphazol...

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Published in:	Biology bulletin of the Russian Academy of Sciences 2023-12, Vol.50 (11), p.3054-3060
Main Authors:	Ponomarev, D. B., Remizov, D. V., Kondakov, A. Yu, Drachyov, I. S., Tikhomirov, P. V., Kudryashov, V. S.
Format:	Article
Language:	English
Subjects:	Biochemistry Biomedical and Life Sciences Cell Biology Ecology Ionizing radiation Leukopenia Life Sciences Modification of Radiation Effects Myelopoiesis Zoology
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creator	Ponomarev, D. B. Remizov, D. V. Kondakov, A. Yu Drachyov, I. S. Tikhomirov, P. V. Kudryashov, V. S.
description	The effects of the drugs naphazoline and filgrastim, upon individual and co-administration, on the course and outcome of combined radiation–mechanical injury were examined in experimental studies in mice. In mice exposed to ionizing radiation at LD 50/30 with a subsequent mechanical injury, naphazoline and filgrastim, upon individual administration, reduced the severity of hemapoiesis impairment of the bone marrow and the proliferative activity of hemapoietic cells, contributing to an increase in survival by 20 and 30%, respectively. Co-administration of naphazoline (prophylactically, 15 min preexposure) and filgrastim (over ten days) has a significant protective effect under specified combined injury, characterized by a 50% increase in survival, a reduced postradiational leukopenia severity, increased colony formation, and myelopoiesis.
doi_str_mv	10.1134/S1062359023110183
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subjects	Biochemistry Biomedical and Life Sciences Cell Biology Ecology Ionizing radiation Leukopenia Life Sciences Modification of Radiation Effects Myelopoiesis Zoology
title	Experimental Study of the Effectiveness of Naphazoline and Co-Administration of Filgrastim in Combined Radiation Injury
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