Alteration of liver function tests in various liver diseases

• Published in: National journal of physiology, pharmacy and pharmacology pharmacy and pharmacology, 2024, Vol.14 (1), p.1-137
• Main Authors: Patel, Bhavin, Trivedi, Naresh
• Format: Article
• Language: English
• Subjects: Age groups; Enzymes; Ethics; Genetic disorders; Hepatitis B; Hospitals; Informed consent; Liver cirrhosis; Liver diseases; Metabolism; Patients; Quality control
• ISSN: 2320-4672; 2231-3206
• DOI: 10.5455/njppp.2023.13.12559202321122023

Background: The burden of liver diseases in India has witnessed a significant rise, spurred by factors such as viral hepatitis, alcoholic liver disease, non-alcoholic fatty liver disease, and a spectrum of metabolic and genetic disorders. Liver function tests (LFTs) serve as invaluable tools in the hands of clinicians, offering insights into the dynamic interplay between hepatic health and various disease processes. This study aims to provide a detailed exploration of the alterations in LFTs associated with various liver diseases prevalent in India. Aim and Objectives: (i) To Identify the various types of Liver diseases; (ii) To evaluate the various liver function tests in various liver diseases. Materials and Methods: The study involved the collection of samples from 100 liver disease patients who seek medical care at C. U. Shah Medical College and Hospital. Informed consent was obtained from all participants and the study protocol was approved by the institutional ethics committee. Results: Our study shows that the prevalence of cirrhosis of liver was 25% among study participants. Majority of liver disease were prevalent in male whereas, mostly affected age group was 51–60 years. Bilirubin was altered in cirrhosis of liver (88%), obstructive jaundice (100%), alcoholic liver disease (80%), viral hepatitis (75%), and in other liver disease (85%). Conclusion: Altered LFT is a useful tool to reach the Etiology of Liver disease. Alterations in liver enzymes as well as HbsAg reactivity are specific tests for cirrhosis of liver and viral hepatitis.