Characteristic of Ag/TiO2–SiO2 bionanocatalysts prepared by sol–gel method as potential antineoplastic compounds

In this study, bionanocatalysts composed of a titanosilicate oxide matrix (TiO 2 –SiO 2 ) impregnated with different concentrations of silver (0.1, 0.5, 1.0, 5.0 and 10 wt%) were prepared by the sol–gel method using silver nitrate (AgNO 3 ) as silver (Ag) source. The physicochemical properties were...

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Bibliographic Details
Published in:Bulletin of materials science 2022-03, Vol.45 (1), p.3, Article 3
Main Authors: López-Goerne, Tessy, Gracia, Alina, Padilla-Godínez, Francisco J, Lottici, Paolo, Silvestre-Albero, Ana M
Format: Article
Language:English
Subjects:
Carbon
Cell growth
Chemistry and Materials Science
Cytotoxicity
Data analysis
Engineering
Fourier transforms
Infrared spectra
Materials Science
Microscopy
Morphology
Photoelectrons
Radiation
Silicon dioxide
Silver
Silver nitrate
Software
Sol-gel processes
Titanium dioxide
Uterine cancer
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Summary:In this study, bionanocatalysts composed of a titanosilicate oxide matrix (TiO 2 –SiO 2 ) impregnated with different concentrations of silver (0.1, 0.5, 1.0, 5.0 and 10 wt%) were prepared by the sol–gel method using silver nitrate (AgNO 3 ) as silver (Ag) source. The physicochemical properties were evaluated by scanning and transmission electron microscopies, Raman and Fourier transform infrared spectra, X-ray photoelectron spectra, and UV–visible spectroscopy. Furthermore, we studied the cytotoxic effect on a cervical uterine cancer cell line as a first approach attending to the potential antineoplastic properties of the Ag/TiO 2 –SiO 2 bionanocatalysts. The bionanocatalysts exhibited no significant differences in morphology or composition independently of the amount of Ag stabilized, with a reduction in particle size proportional to Ag concentration. All samples could achieve cell mortality rates above 91%, obtaining results similar to those of pure AgNO 3 (considered as 100% Ag) from the sample loaded with 1% Ag. The results in this study suggest the possibility of using bionanocatalysts to enhance the intrinsic cytotoxic properties of silver such that a minimum concentration is required to achieve desired results.
ISSN:0250-4707
0973-7669
DOI:10.1007/s12034-021-02570-8