Numerical study of one-dimensional buffered advection–diffusion of calcium and IP3 in a hepatocyte cell

The intracellular calcium signaling plays a crucial role in maintaining chemical homeostatic in all human organelles. In the hepatocyte cell, interdependent calcium and IP 3 dynamics are affected by numerous physiological processes such as advection, diffusion, and buffering. The higher amount of ca...

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Bibliographic Details
Published in:Network modeling and analysis in health informatics and bioinformatics (Wien) 2019-12, Vol.8 (1), p.25
Main Authors: Jagtap, Yogita, Adlakha, Neeru
Format: Article
Language:English
Subjects:
Advection
Applications of Graph Theory and Complex Networks
Binding sites
Bioinformatics
Boundary conditions
Calcium
Calcium (intracellular)
Calcium buffering
Calcium sequestration
Calcium signalling
Computational Biology/Bioinformatics
Computer Science
Electrons
Finite volume method
Health Informatics
Hormones
Intracellular signalling
Kinases
Liver
Mathematical models
Nonlinear differential equations
Organelles
Original Article
Partial differential equations
Phosphatase
Velocity
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Summary:The intracellular calcium signaling plays a crucial role in maintaining chemical homeostatic in all human organelles. In the hepatocyte cell, interdependent calcium and IP 3 dynamics are affected by numerous physiological processes such as advection, diffusion, and buffering. The higher amount of calcium is hazardous to cell; therefore, various factors like influxes, effluxes of calcium from internal storage compartments play vital role for supplying or pumping calcium back into the compartment. IP 3 is needed for calcium release, while the increase in calcium decreases the IP 3 concentration. The one-dimensional nonlinear partial differential equation involving the entire phenomenon under consideration is solved by employing the finite volume method and simulated on MATLAB to study the results. The computational study has been made with and without advection of calcium, without and with buffer, by varying pump rate constant, etc. The results obtained are discussed in the latter part of the paper. The numerical results obtained here shows beautiful patterns of calcium and IP 3 interdependent coordination in a hepatocyte cell.
ISSN:2192-6662
2192-6670
DOI:10.1007/s13721-019-0205-5