Age changes in the number and proliferation of fibroblasts in the human skin

Fibroblasts synthesize all components of the extracellular matrix of the dermis, including collagen, elastin, proteoglycans, and minor proteins. Consequently, the changes in the size and functional status of these cells may disrupt the formation of intercellular substance, which will contribute to t...

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Bibliographic Details
Published in:Advances in gerontology 2011-10, Vol.1 (4), p.299-303
Main Authors: Gunin, G., Kornilova, N. K., Petrov, V. V., Vasilyeva, O. V.
Format: Article
Language:English
Subjects:
Age
Aging
Antibodies
Autopsies
Bone marrow
Cell cycle
Correlation analysis
Extracellular matrix
Fetuses
Fibroblasts
Geriatrics/Gerontology
Gerontology
Inflammation
Medicine
Medicine & Public Health
Older people
Proteins
Skin
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Summary:Fibroblasts synthesize all components of the extracellular matrix of the dermis, including collagen, elastin, proteoglycans, and minor proteins. Consequently, the changes in the size and functional status of these cells may disrupt the formation of intercellular substance, which will contribute to the appearance of outward signs of aging. Therefore, the aim of this study was to investigate age-related changes in the size and proliferation of fibroblasts in the dermis of a human. The work showed that the total number of fibroblasts in the dermis of a human decreases progressively with age. The number of PCNA-positive fibroblasts, which reflects the proliferative activity, also significantly decreased with age. Thus, the reduction in the number of fibroblasts in the dermis with age is partly due to the reduced activity of proliferation.
ISSN:2079-0570
2079-0589
DOI:10.1134/S2079057011040059