Antimicrobial and larvicidal activity of zinc-substituted hydroxyapatite

Mosquitoes transmit serious human infections and cause a number of deaths in tropical and subtropical environment countries every year. In the present work the zinc-substituted hydroxyapatite Ca 5− x Zn x (PO 4 ) 3 OH ( x  = 0, 0.05, 0.2 and 1.0) was synthesized by two different methods: the hydroth...

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Bibliographic Details
Published in:Bulletin of materials science 2020-12, Vol.43 (1), p.218, Article 218
Main Authors: Valarmathi, N, Sabareeswari, K, Sumathi, S
Format: Article
Language:English
Subjects:
Antimicrobial agents
Chemistry and Materials Science
Dengue fever
E coli
Encephalitis
Engineering
Fourier transforms
Functional groups
Hydroxyapatite
Larvae
Materials Science
Methods
Morphology
Mosquitoes
Nanoparticles
Nitrates
Physical properties
Sol-gel processes
Substitutes
Synthesis
Tropical diseases
Zinc
Zinc compounds
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Summary:Mosquitoes transmit serious human infections and cause a number of deaths in tropical and subtropical environment countries every year. In the present work the zinc-substituted hydroxyapatite Ca 5− x Zn x (PO 4 ) 3 OH ( x  = 0, 0.05, 0.2 and 1.0) was synthesized by two different methods: the hydrothermal method and the sol–gel method. The phase formation, functional group and surface morphology of Zn-HAP were authenticated using X-ray diffraction, Fourier transform infrared and scanning electron microscopy-energy-dispersive X-ray spectroscopy, respectively. The antimicrobial activity of the synthesized compounds was tested against different organisms such as Escherichia coli , Staphylococcus aureus and Candida albicans . Moreover, excellent antimicrobial activity was observed for hydrothermal-synthesized (Zn-HAP) compound compared to that of the sol–gel method. The synthesized Zn-HAP nanoparticles were reported for larvicidal activity against the filarial and Japanese encephalitis vector, Culex quinquefasciatus . The hydrothermal-synthesized (1.0 M Zn-HAP) compound exhibited higher larvicidal activity (93 ± 6.62) with minimum lethal concentration LC 50 (33.74 mg ml −1 ) (to kill 50% of the care for larvae of the relevant species) and LC 90 (139.92 mg ml −1 ) (to kill 90% of the treated larvae of the respective species) after 24 h, respectively than that of the sol–gel method.
ISSN:0250-4707
0973-7669
DOI:10.1007/s12034-020-02192-6