Carcinosarcoma of the ovary successfully treated with paclitaxel and carboplatin therapy: two cases

We present two rare cases of carcinosarcoma of the ovary treated successfully with paclitaxel and carboplatin therapy. Case 1: A 79-year-old Japanese woman was diagnosed with carcinosarcoma of the ovary stage IV. We administered neoadjuvant chemotherapy (paclitaxel 180 mg/m 2 and carboplatin AUC 6)....

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Bibliographic Details
Published in:International cancer conference journal 2015-04, Vol.4 (2), p.88-91
Main Authors: Sato, Shimpei, Nishida, Masakazu, Takebayashi, Kanetoshi, Sato, Hatsumi, Ishii, Terukazu, Nasu, Kaei, Narahara, Hisashi
Format: Article
Language:English
Subjects:
Abdomen
Adjuvant therapy
Ascites
Calcification
Cancer therapies
Carboplatin
Case Report
Chemotherapy
Hysterectomy
Lymphatic system
Medicine
Medicine & Public Health
Metastasis
Oncology
Oophorectomy
Ovarian cancer
Ovariectomy
Ovaries
Paclitaxel
Patients
Pleural effusion
Small intestine
Surgery
Surgical Oncology
Surgical outcomes
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Summary:We present two rare cases of carcinosarcoma of the ovary treated successfully with paclitaxel and carboplatin therapy. Case 1: A 79-year-old Japanese woman was diagnosed with carcinosarcoma of the ovary stage IV. We administered neoadjuvant chemotherapy (paclitaxel 180 mg/m 2 and carboplatin AUC 6). After three cycles, she underwent a bilateral salpingo-oophorectomy, hysterectomy and omentectomy as a debulking procedure. She received another three cycles of paclitaxel and carboplatin therapy as adjuvant therapy. She is well without evidence of disease 6 months after the sixth chemotherapy cycle. Case 2: A 74-year-old Japanese woman was diagnosed with carcinosarcoma of the ovary stage IIIc. We performed hysterectomy, bilateral salpingo-oophorectomy, partial resection of small intestine, pelvic lymphadenectomy, omentectomy and low anterior resection of the rectosigmoid colon as the primary debulking surgery. She received six cycles of paclitaxel and carboplatin therapy as adjuvant therapy. She has been recurrence free for 6 years. The standard chemotherapy for ovarian carcinosarcoma is not established, but we think that paclitaxel and carboplatin therapy for progressive ovarian carcinosarcoma as an adjuvant therapy might become a standard chemotherapy if further cases of ovarian carcinosarcoma treated with paclitaxel and carboplatin therapy are reported.
ISSN:2192-3183
2192-3183
DOI:10.1007/s13691-014-0175-5