Influence of AEDG and KE Peptides on Mitochondrial Staining and the Expression of Ribosomal Protein L7A with Aging of the Human Pineal Gland and Thymus Cell In Vitro

New molecular targets for the geroprotective activity of AEDG (epitalon) and KE (vilon) peptides were verified via confocal laser scanning microscopy. It was shown that the aging of pineal and thymic cells in vitro led to a decrease in the staining of MitoTracker Red mitochondria and that there is a...

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Bibliographic Details
Published in:Advances in gerontology 2021-07, Vol.11 (3), p.261-267
Main Authors: Ivko, O. M., Drobintseva, A. O., Leont’eva, D. O., Kvetnoy, I. M., Polyakova, V. O., Linkova, N. S.
Format: Article
Language:English
Subjects:
Aging
Cell growth
Dyes
Endocrine system
Geriatrics/Gerontology
Immune system
Lymphocytes
Medicine
Medicine & Public Health
Metabolism
Mitochondria
Peptides
Production increases
Proteins
Ribonucleic acid
RNA
Thymus gland
Yeast
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Summary:New molecular targets for the geroprotective activity of AEDG (epitalon) and KE (vilon) peptides were verified via confocal laser scanning microscopy. It was shown that the aging of pineal and thymic cells in vitro led to a decrease in the staining of MitoTracker Red mitochondria and that there is a compensatory increase in the synthesis of L7A ribosomal protein. AEDG peptide increased the area of MitoTracker Red mitochondrial staining by 1.5 times and decreased by 22% the expression of ribosomal protein L7A in cultures of human pineal-gland cells with aging. KE peptide increased the area of MitoTracker Red mitochondrial staining by 1.5 times and decreased by 15% the expression of ribosomal protein L7A in cultures of human thymic cells with aging. The area of MitoTracker Red mitochondrial staining decreased and the compensatory expression of L7A ribosomal protein increased with aging of the pineal gland and thymic cells. Presumably, AEDG and KE peptides have a tissue-specific effect that normalizes the functions of mitochondria and ribosomes of pinealocytes and thymocytes.
ISSN:2079-0570
2079-0589
DOI:10.1134/S2079057021030061