Modeling and simulation of glucose insulin glucagon algorithm for artificial pancreas to control the diabetes mellitus

Artificial pancreas systems the courage to remove this risk by taking existing pump technology to a new level. In this paper, we modified the existing model for type 1 diabetes mellitus to discuss different control strategies for the artificial pancreas. A model consists of eight states variables an...

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Bibliographic Details
Published in:Network modeling and analysis in health informatics and bioinformatics (Wien) 2021-12, Vol.10 (1), p.42, Article 42
Main Authors: Tabassum, Muhammad Farhan, Farman, Muhammad, Naik, Parvaiz Ahmad, Ahmad, Aqeel, Ahmad, Aqsa Shamim, Hassan, Saadia Mahmood ul
Format: Article
Language:English
Subjects:
Algorithms
Applications of Graph Theory and Complex Networks
Bioinformatics
Closed loops
Computational Biology/Bioinformatics
Computer Science
Computer simulation
Diabetes
Diabetes mellitus
Diabetes mellitus (insulin dependent)
Epidemics
Equilibrium
Glucagon
Glucose
Health Informatics
Infusion pumps
Insulin
Mathematical models
Metabolism
Observability (systems)
Original Article
Pancreas
Parameters
Partial differential equations
Plasma
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Summary:Artificial pancreas systems the courage to remove this risk by taking existing pump technology to a new level. In this paper, we modified the existing model for type 1 diabetes mellitus to discuss different control strategies for the artificial pancreas. A model consists of eight states variables and various parameters, numerous of which are undefined and complicated to find out correctly. The stability of glucose-insulin in humans has been created and validated the non-negative unique solution. Controllability and observability for the glucose-insulin system is treated for feedback design to develop the artificial pancreas. We design glucose insulin algorithm for whole body having eight sub-compartments according to parameters values given in Liu and Tang (J Theor Biol 252:608–620, 2008) which provide the continues monitoring of glucose and insulin in finite time. Numerical simulation are carried out for closed-loop design which is helpful for the development of artificial pancreas. The developed model provides the estimation values for normal day life to measure the glucose-insulin system in humans.
ISSN:2192-6662
2192-6670
DOI:10.1007/s13721-021-00316-4