Intranasal Perfluorochemical Spray for Preferential Brain Cooling in Sheep

Introduction Hypothermic brain protection has been linked to how rapidly cooling is initiated and how quickly and uniformly the therapeutic hypothermic zone (THZ) is reached. The nasopharyngeal (NP) approach is uniquely suited for preferential brain cooling due to anatomic proximity to the cerebral...

Full description

Saved in:
Bibliographic Details
Published in:Neurocritical care 2008, Vol.8 (3), p.437-447
Main Authors: Wolfson, Marla R., Malone, Daniel J., Wu, Jichuan, Hoffman, John, Rozenberg, Allan, Shaffer, Thomas H., Barbut, Denise
Format: Article
Language:English
Subjects:
Administration, Intranasal
Anesthesia
Animals
Body Temperature - drug effects
Brain - blood supply
Catheterization - methods
Catheters
Cavernous Sinus
Cerebrovascular Circulation
Cooling
Critical Care Medicine
Design
Fluorocarbons - pharmacokinetics
Gas flow
Heat
Hypothermia, Induced - methods
Intensive
Internal Medicine
Ischemia
Male
Medicine
Medicine & Public Health
Neurology
Pulmonary arteries
Sheep
Temperature
Thermocouples
Translational Research
Veins & arteries
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Introduction Hypothermic brain protection has been linked to how rapidly cooling is initiated and how quickly and uniformly the therapeutic hypothermic zone (THZ) is reached. The nasopharyngeal (NP) approach is uniquely suited for preferential brain cooling due to anatomic proximity to the cerebral circulation, cavernous sinus, and carotid arteries. This study explores a novel NP cooling approach employing evaporative characteristics of aerosolized perfluorochemical (PFC). Methods Anesthetized, normotensive sheep ( n  = 30) were instrumented with temperature probes and vascular catheters, then randomized to NP approach (NP-PFC: PFC spray device; n  = 24) or whole body surface (WBS: n  = 6) cooling. Regional temperatures, vital signs, and blood chemistries were assessed serially. Two animals were exposed to double PFC flow rates and PFC was measured in blood during NP-PFC cooling to assess PFC uptake and elimination. Cooling rates were evaluated (ANOVA) as a function of method (NP-PFC versus WBS) and time to reach the brain THZ (i.e., ≤−3.5°C below baseline). Results Independent of region, brain cooling was faster during NP-PFC versus WBS ( P   vascular > rectal cooling rates ( P  
ISSN:1541-6933
1556-0961
DOI:10.1007/s12028-008-9064-0