Effect of ZnO Doping on Biological Properties of SiO2-CaO-P2O5-SrO Bioactive Nanoglasses Synthesized via the Sol–Gel Method

The current research was done to evaluate the effect of zinc on the structural and biological characteristics of 58 s bioactive glasses. To this end, SiO 2 –CaO–P 2 O 5 –SrO–ZnO bioactive nanoglasses containing different content of ZnO (0, 1, 3, and 5 mol.%) were produced by the sol–gel process. To...

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Published in:SILICON 2023-07, Vol.15 (11), p.4835-4844
Main Authors: Azizabadi, Negar, Azar, Parviz Aberoomand, Tehrani, Mohammad Saber, Derakhshi, Pirouz
Format: Article
Language:English
Subjects:
Biocompatibility
Bioglass
Biological activity
Biological properties
Biomedical materials
Body fluids
Bone surgery
Calcium oxide
Chemistry
Chemistry and Materials Science
Environmental Chemistry
Fourier transforms
Hydroxyapatite
Infrared analysis
Infrared spectroscopy
Inorganic Chemistry
Lasers
Materials Science
Nitrates
Optical Devices
Optics
Original Paper
Phosphorus pentoxide
Photonics
Polymer Sciences
Scanning electron microscopy
Silicon dioxide
Sol-gel processes
Strontium oxides
Zinc oxide
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description The current research was done to evaluate the effect of zinc on the structural and biological characteristics of 58 s bioactive glasses. To this end, SiO 2 –CaO–P 2 O 5 –SrO–ZnO bioactive nanoglasses containing different content of ZnO (0, 1, 3, and 5 mol.%) were produced by the sol–gel process. To assess their bioactivity, the specimens were soaked in the simulated body fluid (SBF) solution for 21 days and analyzed employing Fourier transform infrared spectroscopy (FT-IR), x-ray diffraction (XRD), and scanning electron microscopy (SEM) techniques. The results indicated that the bioactive nanoglass sample containing 1 mol.% Zn possessed the highest potential in terms of hydroxyapatite formation. The results obtained by the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay proved the superior biocompatibility of Zn-containing nanoglasses compared to Zn-free samples. Accordingly, the sample containing 1 mol.% Zn was considered a suitable candidate for medical applications.
doi_str_mv 10.1007/s12633-023-02399-2
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subjects Biocompatibility
Bioglass
Biological activity
Biological properties
Biomedical materials
Body fluids
Bone surgery
Calcium oxide
Chemistry
Chemistry and Materials Science
Environmental Chemistry
Fourier transforms
Hydroxyapatite
Infrared analysis
Infrared spectroscopy
Inorganic Chemistry
Lasers
Materials Science
Nitrates
Optical Devices
Optics
Original Paper
Phosphorus pentoxide
Photonics
Polymer Sciences
Scanning electron microscopy
Silicon dioxide
Sol-gel processes
Strontium oxides
Zinc oxide
title Effect of ZnO Doping on Biological Properties of SiO2-CaO-P2O5-SrO Bioactive Nanoglasses Synthesized via the Sol–Gel Method
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