High performance surface plasmon resonance-based photonic crystal fiber biosensor for cancer cells detection

• Published in: European physical journal plus 2022-04, Vol.137 (4), p.417, Article 417
• Main Authors: Meshginqalam, Bahar, Barvestani, Jamal
• Format: Article
• Language: English
• Subjects: Applied and Technical Physics; Atomic; Biosensors; Cancer; Comparative studies; Complex Systems; Condensed Matter Physics; Crystal fibers; Design; Figure of merit; Finite element method; Gold; Mathematical and Computational Physics; Molecular; Nanowires; Optical and Plasma Physics; Performance enhancement; Photonic crystals; Physics; Physics and Astronomy; Refractivity; Regular Article; Resonance; Sensors; Spectral sensitivity; Surface plasmon resonance; Theoretical
• ISSN: 2190-5444; 2190-5444
• DOI: 10.1140/epjp/s13360-022-02618-6

In order to detect cancer early and reduce fatality, a novel highly sensitive surface plasmon resonance-based photonic crystal fiber sensor with gold nanowires is suggested for six different cancer cells detection. Double gold nanowires are used as plasmonic materials where their sizes and also the geometrical parameters of the fiber are examined to obtain the best performance of the proposed sensor. The sensor response based on the refractive index variations upon cancerous cells detection is analyzed using the full-vectorial finite element method. Also, a comparative study of the single and double gold nanowires-based biosensor is done which shows noticeable performance enhancement by employing double gold nanowires. Our results show that the presented structure has high performance responses for almost six types of cancers. It displays the highest spectral and amplitude sensitivities as 53,571 nm/RIU and 2582 RIU −1 for MCF-7 and PC12 cells, respectively. Great sensitivity and resolution together with suitable figure of merit and low loss values introduce the suggested biosensor as an appropriate sensing platform for early and precise detection of cancer cells.