Experimental Studies of Geroprotective and Anti-Aging Effects of Chemical Compounds of Portulaca oleracea L. (Review)

The analysis presented in the review of publications shows that extract of Portulaca oleracea L. or its individual components (polysaccharides, oleracea, alkaloids tetrahydroisoquinoline operatein E) is able to increase the lifespan of laboratory animals, to activate telomerase and increase telomere...

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Bibliographic Details
Published in:Advances in gerontology 2022-06, Vol.12 (2), p.122-127
Main Authors: Berezutsky, M. A., Durnova, N. A., Sheremetyewa, A. S., Matvienko, U. A., Kurchatova, M. N.
Format: Article
Language:English
Subjects:
Aging
Antioxidants
Chemical compounds
Dementia
Disease
DNA damage
Enzymes
Experiments
Flavonoids
Free radicals
Geriatrics/Gerontology
Insulin
Insulin-like growth factors
Laboratory animals
Life expectancy
Lipid peroxidation
Medicine
Medicine & Public Health
Nematodes
Telomerase
Yeast
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Summary:The analysis presented in the review of publications shows that extract of Portulaca oleracea L. or its individual components (polysaccharides, oleracea, alkaloids tetrahydroisoquinoline operatein E) is able to increase the lifespan of laboratory animals, to activate telomerase and increase telomere length, and to provide antioxidant and antiosteoclastogenic impact. Various neuroprotective effects (improvement of memory and learning ability, inhibition of acetylcholinesterase, protection of dopaminergic neurons, improvement of motor functions, etc.) are of interest for the prevention of syndromes associated with age-related degradation of the nervous system such as Alzheimer’s and Parkinson’s diseases. In addition, regular consumption of vegetable portulaca in food leads to a decrease in the percentage of cancer and cardiovascular diseases, which also directly provides an increase in the average life expectancy of the population.
ISSN:2079-0570
2079-0589
DOI:10.1134/S2079057022020047