CD3 and EBER double positive cells in bone marrow are a diagnostic aid for EBV-positive T-cell lymphoproliferative disorders of childhood

We describe a case of Epstein–Barr virus (EBV)-positive T-cell lymphoproliferative disorders (EBV+ T-cell LPD) of childhood. The patient presented with high fever, jaundice, hepatosplenomegaly, pancytopenia, and disseminated intravascular coagulation (DIC). On admission, liver biopsy could not be co...

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Bibliographic Details
Published in:International cancer conference journal 2012-03, Vol.1 (1), p.33-36
Main Authors: Yamada, Yuri, Kamiunten, Ayako, Hidaka, Tomonori, Sekine, Masafumi, Marutsuka, Kousuke, Katayose, Keiko, Kubuki, Yoko, Iwakiri, Hisanori, Hasuike, Satoru, Tsuchimochi, Mai, Nakamura, Kenichi, Yamamoto, Shojirou, Otsubo, Yoshinori, Kusumoto, Norihisa, Eto, Toshiharu, Nagata, Kenji, Kitanaka, Akira, Shimoda, Kazuya
Format: Article
Language:English
Subjects:
Antigens
Biopsy
Bone marrow
Case Report
CD3 antigen
Chemotherapy
Childhood
Children
Cytotoxicity
Diagnosis
Disseminated intravascular coagulation
Epstein-Barr virus
Fever
Genetic testing
Genotype & phenotype
Immunoproliferative diseases
Infections
Jaundice
Laboratories
Liver
Lymphatic system
Lymphocytes
Lymphocytes T
Lymphoma
Medicine
Medicine & Public Health
Oncology
Pancytopenia
Spleen
Surgical Oncology
T cell receptors
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Summary:We describe a case of Epstein–Barr virus (EBV)-positive T-cell lymphoproliferative disorders (EBV+ T-cell LPD) of childhood. The patient presented with high fever, jaundice, hepatosplenomegaly, pancytopenia, and disseminated intravascular coagulation (DIC). On admission, liver biopsy could not be conducted due to DIC. The small but definitive number of abnormal lymphocytes in bone marrow (BM) was indicative of malignant lymphoma or related diseases. The diagnosis of EBV+ T-cell LPD of childhood was tentatively made on the basis of the presence of CD3 and EBER double positive cells in BM. We started chemotherapy, which promptly resolved the symptoms and DIC. Later the diagnosis was confirmed by the T-cell receptor rearrangement and a single band for the EBV terminal repeat region by Southern blot analysis of BM cells. The detection of EBER-positive CD3 cells in BM is a diagnostic aid for EBV+ T-cell LPD of childhood.
ISSN:2192-3183
2192-3183
DOI:10.1007/s13691-011-0005-y