Amyloid Cardiomyopathy in Older Adults

Purpose of Review Wild type transthyretin cardiac amyloidosis (ATTRwt, formerly called senile cardiac amyloidosis) is almost exclusively a disorder of adults over 60 years old and represents a quintessential type of diastolic heart failure in the older adult population. Cardiac amyloidosis is an inf...

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Bibliographic Details
Published in:Current geriatrics reports 2022-03, Vol.11 (1), p.1-9
Main Authors: Bhattacharya, Priyanka T., Maurer, Mathew S., Smiley, Dia A.
Format: Article
Language:English
Subjects:
Age
Amyloidosis
Aortic stenosis
Cardiac arrhythmia
Cardiomyopathy
Cardiovascular Disease in the Elderly (M Chen
Carpal tunnel syndrome
Dyspnea
Electrocardiography
Epidemiology
Geriatrics/Gerontology
Heart failure
Hypotension
Kidney diseases
Males
Medicine
Medicine & Public Health
Neurology
Pain Medicine
Pathophysiology
Patients
Peripheral neuropathy
Proteins
Psychopharmacology
Rheumatology
Section Editor
Spinal stenosis
Topical Collection on Cardiovascular Disease in the Elderly
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Summary:Purpose of Review Wild type transthyretin cardiac amyloidosis (ATTRwt, formerly called senile cardiac amyloidosis) is almost exclusively a disorder of adults over 60 years old and represents a quintessential type of diastolic heart failure in the older adult population. Cardiac amyloidosis is an infiltrative/restrictive cardiomyopathy that causes heart failure, atrial and ventricular arrhythmias, and conduction disease, and is associated with significant morbidity and mortality. Early suspicion by geriatricians including clinical clues or suggestive features when coupled with non-invasive cardiac testing that delineates a discordance between the wall thickness on echocardiography and the voltage on an electrocardiogram along with other suggestive findings on imaging of cardiac amyloidosis is paramount because early treatment can significantly improve prognosis. Recent Findings With the advent of a non-invasive method to diagnose ATTRwt without a biopsy and the development of effective therapies, there is an increasing interest in this condition. Summary The goal of this review is to provide clinical and testing guides and pearls, for early suspicion and detection, and subsequent referral to specialist cardiologists and amyloid specialists for further management and treatment.
ISSN:2196-7865
2196-7865
DOI:10.1007/s13670-022-00374-0