RETRACTED: Omega-3 Self-Nanoemulsion Role in Gastroprotection against Indomethacin-Induced Gastric Injury in Rats

Peptic ulcer disease is an injury of the alimentary tract that leads to a mucosal defect reaching the submucosa. This study aimed to formulate and optimize omega-3 oil as a self-nanoemulsifying drug delivery system (SNEDDS) to achieve oil dispersion in the nano-range in the stomach to augment omega-...

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Bibliographic Details
Published in:Pharmaceutics 2020-02, Vol.12 (2), p.140
Main Authors: Ahmed, Osama, Fahmy, Usama, Bakhaidar, Rana, El-Moselhy, Mohamed, Okbazghi, Solomon, Ahmed, Al-Shaimaa, Hammad, Asmaa, Alhakamy, Nabil
Format: Article
Language:English
Subjects:
Animals
Bioavailability
Drug delivery systems
Drug dosages
Motility
Nanoemulsions
Nonsteroidal anti-inflammatory drugs
Oxidative stress
Software
Stomach
Surfactants
Ulcers
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Summary:Peptic ulcer disease is an injury of the alimentary tract that leads to a mucosal defect reaching the submucosa. This study aimed to formulate and optimize omega-3 oil as a self-nanoemulsifying drug delivery system (SNEDDS) to achieve oil dispersion in the nano-range in the stomach to augment omega-3 oil gastric ulcer protection efficacy. Three SNEDDS components were selected as the design factors: the concentrations of the oil omega-3 (X1, 10–30%), the surfactant tween 20 and Kolliphor mixture (X2, 20–40%), and the cosurfactant transcutol (X3, 40–60%). The mixture experimental design proposed twenty-three formulations with varying omega-3 SNEDDS formulation component percentages. The optimized omega-3 SNEDDS formula was investigated for gastric ulcer protective effects by evaluating the ulcer index and by the determination of gastric mucosa oxidative stress parameters. Results revealed that optimized omega-3-SNEDDS achieved significant improvement in the gastric ulcer index in comparison with pure omega-3 oil. Histopathological findings confirmed the protective effect of the formulated optimized omega-3 SNEDDS in comparison with omega-3 oil. These findings suggest that formulation of omega-3 in the form of a SNEDDS would be more effective in gastric ulcer protection than the administration of omega-3 as a crude oil.
ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics12020140