Relationship of NLRP3 Inflammasome with Oral Health

Purpose of Review The aim of this review is whether the NLRP3 inflammasome is associated with oral health and to understand whether the biology of the NLRP3 inflammasome is for the prevention of oral inflammatory and immunological disorders. Recent Findings According to the studies, understanding th...

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Bibliographic Details
Published in:Current oral health reports 2023-12, Vol.10 (4), p.196-202
Main Author: Karaaslan, Seyhan
Format: Article
Language:English
Subjects:
Arthritis
Bacteria
Bacterial infections
Biofilms
Cardiovascular disease
Cytokines
Diabetes
Gum disease
Immune system
Immunology
Infections
Inflammation
Inflammatory diseases
Medicine
Medicine & Public Health
Oral and Maxillofacial Surgery
Oral cancer
Oral diseases
Oral hygiene
Pathogenesis
Pathogens
Proteins
Topical Collection on Systemic Diseases
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Summary:Purpose of Review The aim of this review is whether the NLRP3 inflammasome is associated with oral health and to understand whether the biology of the NLRP3 inflammasome is for the prevention of oral inflammatory and immunological disorders. Recent Findings According to the studies, understanding the biology of the NLRP3 inflammasome is essential for the treatment and prevention of oral inflammatory and immunological disorders. It has been observed that the pathways of chronic inflammatory diseases are similar both in oral and systemic diseases. Recent investigations have demonstrated that inflammasomes play important roles in osteogenesis and bone homeostasis. Other findings showed that NLRP3 controls osteoclast differentiation to control bone resorption in periodontitis. Recent research has shown that the immune response of the host is restricted by this controlled antigen-specific T-cell immunosuppressive function, which supports the persistence of periodontal infection. Summary In this review, we summarized for the first time the most recent research on the role of inflammation-related cytokines and NLRP3 in oral health. Understanding the role of inflammasomes in oral health could lead to the development of new therapeutic strategies for these conditions.
ISSN:2196-3002
2196-3002
DOI:10.1007/s40496-023-00350-3