Simulation of energy absorption and dose of ionizing radiation on spike of SARS-CoV-2 and comparing it with human mortality statistics, using Geant4-DNA toolkit

In this study, variant of concern alpha, gamma and omicron and variant of interest kappa SARS-CoV-2 were simulated by Geant4 tool. Electron, alpha and X-ray beams with different energies hit spike protein, which were located in a box filled with water, and the absorbed energy and dose values were ex...

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Bibliographic Details
Published in:European physical journal plus 2024-01, Vol.139 (1), p.103, Article 103
Main Authors: Jalili Torkamani, Mehrdad, Zolfagharpour, Farhad, Sayyah-Koohi, Pooneh, Moradi, Maryam, Karami, Chiman
Format: Article
Language:English
Subjects:
Alpha rays
Amino acids
Antibodies
Applied and Technical Physics
Atomic
Complex Systems
Condensed Matter Physics
COVID-19
Electron beams
Energy
Energy absorption
Enzymes
Ionizing radiation
Mathematical and Computational Physics
Molecular
Mutation
Optical and Plasma Physics
Physics
Physics and Astronomy
Proteins
Radiation
Radiation dosage
Regular Article
Severe acute respiratory syndrome coronavirus 2
Simulation
Statistical analysis
Theoretical
Viruses
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Summary:In this study, variant of concern alpha, gamma and omicron and variant of interest kappa SARS-CoV-2 were simulated by Geant4 tool. Electron, alpha and X-ray beams with different energies hit spike protein, which were located in a box filled with water, and the absorbed energy and dose values were extracted by these proteins. By comparing the amount of energy and absorbed dose spikes with the prevalence rate and statistical analysis of countries affected by the mentioned variants, our study has indicated that there is a reverse relation between absorbed dose and prevalence rate of studied variants. Moreover, the number of protein chains in the spike could play an important role in the amount of energy and absorbed dose. The greater the number of protein chains present in the spike, the less energy and absorbed dose it contains, and the more widespread the variant is likely to be.
ISSN:2190-5444
2190-5444
DOI:10.1140/epjp/s13360-024-04928-3