Unusual presentation of disseminated cryptococcal infection complicated by myocarditis in a heart transplant recipient

Background Cryptococcus neoformans is the third most common cause of invasive fungal infection in solid organ transplant (SOT) recipients. While cryptococcal infection can involve any organ, cases of myocarditis are exceedingly rare. Methods A retrospective chart review was completed for this case r...

Full description

Saved in:
Bibliographic Details
Published in:Pediatric transplantation 2024-02, Vol.28 (1), p.e14585-n/a
Main Authors: Barros, Kathryn, Tepper, John William, Ramchandani, Juhi, Kelley, Meagan Kristine, Kussin, Michelle L., Israel, Emily N., Tompkins, Madeline G., Alali, Muayad
Format: Article
Language:English
Subjects:
Adult
Biopsy
Cryptococcosis - complications
Cryptococcosis - diagnosis
Cryptococcosis - drug therapy
cryptococcus
Cryptococcus neoformans
Fungal infections
Heart diseases
Heart transplantation
Heart Transplantation - adverse effects
Humans
Myocarditis
Myocarditis - complications
Myocarditis - diagnosis
orthotopic heart transplant
Retrospective Studies
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Cryptococcus neoformans is the third most common cause of invasive fungal infection in solid organ transplant (SOT) recipients. While cryptococcal infection can involve any organ, cases of myocarditis are exceedingly rare. Methods A retrospective chart review was completed for this case report. Results We present the case of a 21‐year‐old heart transplant recipient who developed disseminated cryptococcal infection with biopsy‐proven cryptococcal myocarditis. Conclusions Cryptococcal disease in SOT recipients poses diagnostic and therapeutic challenges. There are no current guidelines for the duration of cryptococcal myocarditis treatment. Repeat myocardial biopsy may play a role in guiding length of therapy.
ISSN:1397-3142
1399-3046
DOI:10.1111/petr.14585