Peptide Amphiphiles as Biodegradable Adjuvants for Efficient Retroviral Gene Delivery (Adv. Healthcare Mater. 4/2024)

Gene Therapy Gene therapy requires additives to efficiently deliver therapeutic viruses to cells. However, these additives typically rely on the formation of potentially harmful aggregates. In article 2301364, Jan Münch, Christopher V. Synatschke, Tanja Weil, and co‐workers develop peptide amphiphil...

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Bibliographic Details
Published in:Advanced healthcare materials 2024-02, Vol.13 (4), p.n/a
Main Authors: Kaygisiz, Kübra, Rauch‐Wirth, Lena, Iscen, Aysenur, Hartenfels, Jan, Kremer, Kurt, Münch, Jan, Synatschke, Christopher V., Weil, Tanja
Format: Article
Language:English
Subjects:
Additives
Adjuvants
Aggregates
Cell therapy
Gene therapy
Gene transfer
Lymphocytes
Lymphocytes T
Peptides
Viruses
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Summary:Gene Therapy Gene therapy requires additives to efficiently deliver therapeutic viruses to cells. However, these additives typically rely on the formation of potentially harmful aggregates. In article 2301364, Jan Münch, Christopher V. Synatschke, Tanja Weil, and co‐workers develop peptide amphiphiles that promote the uptake of viruses while drastically reducing the formation of aggregates. Thereby peptide amphiphiles have great potential for therapeutic gene delivery, such as CAR‐T cell therapy.
ISSN:2192-2640
2192-2659
DOI:10.1002/adhm.202470026