Search for Potential Epitopes in the Envelope Protein of the African Swine Fever Virus

The spatial structure of the envelope protein of African swine fever (ASF) virus is modeled; its topology relative to the cell membrane is calculated; the B- and T-cell epitopes are predicted for this protein; and their immunogenecity, allergenicity, and toxicity are estimated. The variability of pr...

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Bibliographic Details
Published in:Crystallography reports 2023-12, Vol.68 (6), p.967-974
Main Authors: Kolesnikov, I. A., Timofeev, V. I., Ermakov, A. V., Ivanovsky, A. S., Dyakova, Yu. A., Pisarevsky, Yu. V., Kovalchuk, M. V.
Format: Article
Language:English
Subjects:
Amino acids
Cell membranes
Crystallography and Scattering Methods
Crystallography in Biology and Medicine
Fever
Physics
Physics and Astronomy
Proteins
Swine
Topology
Viruses
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Summary:The spatial structure of the envelope protein of African swine fever (ASF) virus is modeled; its topology relative to the cell membrane is calculated; the B- and T-cell epitopes are predicted for this protein; and their immunogenecity, allergenicity, and toxicity are estimated. The variability of protein amino acids and the conservativity of the found epitopes are studied. It is shown that a new peptide vaccine against ASF can be developed based on the found epitopes.
ISSN:1063-7745
1562-689X
DOI:10.1134/S1063774523601077