Supercritical Antisolvent Precipitation of Levofloxacin Hydrochloride from a Single-Phase and a Two-Phase CO2–Dimethylformamide Mixture

The effect of pressure on the size and morphology of particles of levofloxacin hydrochloride precipitated by supercritical antisolvent precipitation was studied. It was shown that crystallization of levofloxacin from the two-phase system CO 2 –dimethylformamide–levofloxacin hydrochloride gives parti...

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Bibliographic Details
Published in:Russian journal of physical chemistry. B 2023-12, Vol.17 (8), p.1657-1664
Main Authors: Vorobei, A. M., Rubtsov, Ya. P., Zuev, Ya. I., Parenago, O.O.
Format: Article
Language:English
Subjects:
Antibiotics
Binary systems
Carbon dioxide
Chemistry
Chemistry and Materials Science
Crystallization
Dimethylformamide
Physical Chemistry
Pressure effects
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Summary:The effect of pressure on the size and morphology of particles of levofloxacin hydrochloride precipitated by supercritical antisolvent precipitation was studied. It was shown that crystallization of levofloxacin from the two-phase system CO 2 –dimethylformamide–levofloxacin hydrochloride gives particles with a bimodal size distribution. Crystallization from a single-phase system is accompanied by a change in the mechanism of mixing of CO 2 and solution and, as a consequence, yields particles with a unimodal size distribution. For the first time, liquid–gas equilibrium curves for the CO 2 –dimethylformamide– levofloxacin hydrochloride system at a temperature of 40°C were constructed.
ISSN:1990-7931
1990-7923
DOI:10.1134/S1990793123080109