Iron and Molybdenum Content in the Immune-Privileged Organs of Rats upon the Administration of Nanocluster Porous Spherical Keplerate-Type Polyoxometalate {Mo72Fe30}

• Published in: Nanobiotechnology Reports (Online) 2023-12, Vol.18 (6), p.945-951
• Main Authors: Ostroushko, A. A., Gette, I. F., Danilova, I. G., Medvedeva, S. Yu, Koveza, E. V., Andreeva, M. A., Morozova, M. V., Tonkushina, M. O.
• Format: Article
• Language: English
• Subjects: Accumulation; Anemia; Blood-brain barrier; Chemistry and Materials Science; Industrial and Production Engineering; Iron; Machines; Manufacturing; Materials Science; Molybdenum; Nanobiomedicine and Nanopharmaceuticals; Nanoclusters; Nanotechnology; Organs; Penetration resistance; Polyoxometallates; Processes
• ISSN: 2635-1676; 1995-0780; 2635-1684; 1995-0799
• DOI: 10.1134/S2635167623601079

Studies of the concentration of iron and molybdenum in the immune-privileged organs of rats without a pathology and after simulating posthemorrhagic anemia, which received intramuscular injections of Keplerate-type nanocluster porous spherical polyoxometalate (POM) {Mo 72 Fe 30 }, are conducted. The blood–testis barrier is the most resistant to the penetration of the components of POM, the blood–brain and blood–ocular barriers possess a lower resistance (accumulation of iron after 30 injections of POM), and the blood–thymus barrier is the least resistant. The borrowing of iron from immune-privileged organs such as the brain, eyeballs, and thymus occurs in the early stages (1 to 7 days) of posthemorrhagic anemia. Posthemorrhagic anemia decreases the resistance of the blood–brain barrier and is accompanied by the excessive accumulation of iron after seven injections of POM.