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Synthesis and Anti-VIBRIO Activity of Gallic Acid Derivatives Containing Thiosemicarbazide
In order to explore new gallic acid derivatives with high antibacterial activity, we synthesize a series of new 1-(3,4,5-trihydroxybenzoyl)-4-(substituted benzoyl)thiosemicarbazide and evaluate their activities against Vibrio harveyi , Vibrio cholerae , Vibrio parahaemolyticus , and Vibrio vulnificu...
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Published in: | Chemistry of natural compounds 2024, Vol.60 (1), p.110-114 |
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Main Authors: | , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites |
Online Access: | Get full text |
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Summary: | In order to explore new gallic acid derivatives with high antibacterial activity, we synthesize a series of new 1-(3,4,5-trihydroxybenzoyl)-4-(substituted benzoyl)thiosemicarbazide and evaluate their activities against
Vibrio harveyi
,
Vibrio cholerae
,
Vibrio parahaemolyticus
, and
Vibrio vulnificus in vitro
. Through the experiments, we found that compound
7d
has the best inhibitory activity against
V. harveyi
and
V. cholerae
, the minimum inhibitory concentration (MIC) values were 0.0078 mg/mL and 0.0156 mg/mL; compound
7h
has the best inhibitory activity against
V. parahaemolyticus
and
V. vulnificus
, with MIC values of 0.0313 mg/mL and 0.0625 mg/mL. |
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ISSN: | 0009-3130 1573-8388 |
DOI: | 10.1007/s10600-024-04264-z |