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Synthesis and Anti-VIBRIO Activity of Gallic Acid Derivatives Containing Thiosemicarbazide

In order to explore new gallic acid derivatives with high antibacterial activity, we synthesize a series of new 1-(3,4,5-trihydroxybenzoyl)-4-(substituted benzoyl)thiosemicarbazide and evaluate their activities against Vibrio harveyi , Vibrio cholerae , Vibrio parahaemolyticus , and Vibrio vulnificu...

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Bibliographic Details
Published in:Chemistry of natural compounds 2024, Vol.60 (1), p.110-114
Main Authors: Gao, Tian-tian, Liang, Xin-wen, Qiu, Min, Hu, Ji-liang, Liu, Qiang, Zhang, Jian-long, Wu, Jing-yi, Han, Qing, Liu, Wei-wei
Format: Article
Language:English
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Summary:In order to explore new gallic acid derivatives with high antibacterial activity, we synthesize a series of new 1-(3,4,5-trihydroxybenzoyl)-4-(substituted benzoyl)thiosemicarbazide and evaluate their activities against Vibrio harveyi , Vibrio cholerae , Vibrio parahaemolyticus , and Vibrio vulnificus in vitro . Through the experiments, we found that compound 7d has the best inhibitory activity against V. harveyi and V. cholerae , the minimum inhibitory concentration (MIC) values were 0.0078 mg/mL and 0.0156 mg/mL; compound 7h has the best inhibitory activity against V. parahaemolyticus and V. vulnificus , with MIC values of 0.0313 mg/mL and 0.0625 mg/mL.
ISSN:0009-3130
1573-8388
DOI:10.1007/s10600-024-04264-z