In vitro studies of a novel liposomal formulation for safe and efficient iron delivery

Anemia of chronic diseases is the most popular type of anemia. Treatment of such conditions is based on iron supplementation. However, chronic conditions are accompanied by increased activity of hepcidin, which significantly limits iron absorption from traditional supplementation forms. Modern lipos...

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Bibliographic Details
Published in:European journal of lipid science and technology 2024-02, Vol.126 (2), p.n/a
Main Authors: Szostak‐Paluch, Kamila, Drabik, Dominik, Jędruchniewicz, Natalia, Dwornikowska‐Dąbrowska, Mariola
Format: Article
Language:English
Subjects:
Absorption
Anemia
Caco‐2
Chronic conditions
Chronic illnesses
Cytotoxicity
Dextran
Dextrans
Encapsulation
ferric hydroxide dextran complex
Ferric oxide
ferrous gluconate
ferrous sulfate
Hepcidin
Iron
Macromolecules
Reactive oxygen species
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Summary:Anemia of chronic diseases is the most popular type of anemia. Treatment of such conditions is based on iron supplementation. However, chronic conditions are accompanied by increased activity of hepcidin, which significantly limits iron absorption from traditional supplementation forms. Modern liposomal technologies allow for efficient encapsulation of macromolecules, which can result in a significant absorption improvement. The presented results show an encapsulation efficiency of more than 90% of iron‐dextran complexes, with a decrease in cytotoxicity and reactive oxygen species generation. Practical Application: These results can be used to prepare novel liposomal iron ion formulation with high encapsulation efficiency due to the appliance of iron(III) oxide complex with dextran. Characterization and encapsulation efficiency of iron liposomal formulation with a particular focus on the influence of iron salt selection and solvent type. These formulations undergo rigorous assessment through their interaction with Caco‐2 cells, encompassing evaluations of cytotoxicity and the generation of reactive oxygen species (ROS).
ISSN:1438-7697
1438-9312
DOI:10.1002/ejlt.202300217