The relationship between G1 (c.260 G>A) and G4 (c.721 G>A) polymorphisms in the GDF9 gene and the litter size of sheep: A meta-analysis study

Objective: The results of GI and G4 polymorphisms as litter-size (IS) markers of ewes remain contradictory. The aim was to evaluate the impact of G1 (c.260 G>A) and G4 (c.721 G>A) polymorphisms on the IS of sheep by synthesizing data from multiple previous studies. Methods: Data were extracted...

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Bibliographic Details
Published in:Journal of advanced veterinary and animal research 2023-12, Vol.10 (4), p.599-607
Main Authors: Budiyanto, Agung, Hartanto, Slamet, Widayanti, Ríni, Setyawan, Erif Maha Nugraha, Wardono, Heru Pončo, Gustari, Sri
Format: Article
Language:English
Subjects:
Bias
Fertility
Gene polymorphism
Genes
Genetic markers
Genotype & phenotype
Genotypes
Heterogeneity
Investigations
Litter size
Meta-analysis
Polymorphism
Sheep
Software
Statistical analysis
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Summary:Objective: The results of GI and G4 polymorphisms as litter-size (IS) markers of ewes remain contradictory. The aim was to evaluate the impact of G1 (c.260 G>A) and G4 (c.721 G>A) polymorphisms on the IS of sheep by synthesizing data from multiple previous studies. Methods: Data were extracted from 14 eligible articles. The genotypes of GI and G4 polymorphisms were homozygous wild-type (WW), heterozygous (WM), and homozygous mutanttype (MM). The standardized mean difference (SMD) method using random effect models was employed to determine the effect size of GI and G4 polymorphisms on IS under dominant, recessive, additive, and co-dominant genetic models. Heterogeneity was analyzed with the 12 statistic index. Publication bias was depicted with funnel plots and tested by Egger's and Begg's tests. Results: The study showed that the correlation between G1 polymorphism and IS in sheep was not significant (p > 0.05) under all genetic models. The influence of G4 polymorphism on the IS of sheep was found significantly (p < 0.05) under dominant [SMD = 0.28, 12 = 0% (no heterogeneity)] and co-dominant [SMD = -0.14,12 = 36% (moderate heterogeneity)] genetic models. The WM genotype of G4 polymorphism increased IS, while the MM genotype reduced IS in sheep. Publication bias among GI and G4 polymorphism studies was absent in all genetic models. Conclusion: Thus, the study revealed that G4 polymorphism could be a potential genetic marker for IS in ewes. On the contrary, G1 polymorphism has no association with the IS of ewes.
ISSN:2311-7710
DOI:10.5455/javar.2023J715