Preparation, Characterization, and Biological Activity of Mixed Schiff Base Ligand Complexes with Amino Acid L-Proline

The present study involves the synthesis and characterization of complexes of [Cr(III), Fe(III), Co(II), and Ni(II)] with Schiff base and L-proline using 4-dimethylaminobenzaldehyde and 4-aminoantipyrine as reactants. The complexes were characterized using various spectroscopic techniques such as in...

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Bibliographic Details
Published in:Russian journal of general chemistry 2023-12, Vol.93 (Suppl 4), p.S1016-S1025
Main Authors: Majeed, N. M., Obaid, S. M. H., Raheema, M. H., Al-Noor, T. H., Al-Ayash, S. R., Abdou, A.
Format: Article
Language:English
Subjects:
Amines
Amino acids
Biological activity
Biological effects
Carboxyl group
Chelating agents
Chelation
Chemical properties
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Cobalt
Imines
Infrared spectroscopy
Iron
Ligands
Magnetic moments
Mass spectrometry
Melting points
Nitrogen
Oxygen atoms
Proline
Schiff bases
Spectrum analysis
Trivalent chromium
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Summary:The present study involves the synthesis and characterization of complexes of [Cr(III), Fe(III), Co(II), and Ni(II)] with Schiff base and L-proline using 4-dimethylaminobenzaldehyde and 4-aminoantipyrine as reactants. The complexes were characterized using various spectroscopic techniques such as infrared and UV-Vis spectroscopy, mass spectrometry, melting point and conductivity measurements. The formulated complexes are [M(L)(Pro) 2 ]Cl, where M = Fe(III),Cr(III), and [M(L)(Pro) 2 ], where M = Co(II), Ni(II). The ligands Schiff base and L-proline were found to act as bidentate chelating agents. L-Proline coordinates with the amine group’s carboxyl group and nitrogen atom, while Schiff base coordinates through the nitrogen and oxygen atoms. The complexes have been assigned an octahedral geometry based on electronic spectral and magnetic moment studies. Furthermore, the results of the biological activity of the complexes and ligands showed good results against gram-positive and gram-negative bacteria.
ISSN:1070-3632
1608-3350
DOI:10.1134/S1070363223170176