Front Cover Picture: Synthesis of Benzofluorene, Benzofluorene, and Benzofluoranthene via a Lewis Acid‐Catalyzed Prins‐Type Cycloaromatization: Application to the Total Synthesis of Viridistratin A

The front cover illustrates the streamlined synthesis of representative non‐alternant polycyclic aromatic hydrocarbons through Lewis acid‐catalyzed Prins‐type cycloaromatization (on the earth). Notable features of the catalytic reaction encompass air tolerance, high productivity, remarkably short re...

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Bibliographic Details
Published in:Advanced synthesis & catalysis 2024-02, Vol.366 (3), p.323-323
Main Authors: Jeong, Myeonggyo, Yoon, Moonsang, Nguyen, Long Huu, Kim, Soyeong, Han, Jinhee, Cong So Tran, Kim, Jisu, Jeyun Jo, Young‐Suk Jung, Jin‐Wook Yoo, Yun, Hwayoung
Format: Article
Language:English
Subjects:
Lewis acid
Polycyclic aromatic hydrocarbons
Productivity
Synthesis
Online Access:Get full text
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Summary:The front cover illustrates the streamlined synthesis of representative non‐alternant polycyclic aromatic hydrocarbons through Lewis acid‐catalyzed Prins‐type cycloaromatization (on the earth). Notable features of the catalytic reaction encompass air tolerance, high productivity, remarkably short reaction times, and scalability. The plausible mechanism suggests that Prins‐type benzannulation competes with oxonium‐ene cyclization. The robustness and high productivity of the key reaction allowed the application towards total synthesis of natural benzo[j]fluoranthene, viridistratin A (on the moon). Details can be found in the Communication by Hwayoung Yun and co‐workers (M. Jeong, M. Yoon, L. H. Nguyen, S. Kim, J. Han, C. S. Tran, J. Kim, J. Jo, Y.‐S. Jung, J.‐W. Yoo, H. Yun, Adv. Synth. Catal. 2024, 366, 390–395, DOI: 10.1002/adsc.202300600).
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.202301361