Glycosides with galloyl groups from Balakata baccata and their antineuroinflammatory activities

Seven new glycosides (1 − 7) with galloyl groups and two known kaempferol glycosides (8 and 9) were obtained from the overground parts of Balakata baccata. The structures of the new compounds were determined by comprehensive spectroscopic analyses. The rarely seen allene moiety in compounds 6 and 7...

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Bibliographic Details
Published in:Natural product research 2024-03, Vol.38 (6), p.947-955
Main Authors: Zhao, Hai-Yan, He, Shuang, Lan, Qian, Su, Bao-Jun, Wang, Heng-Shan, Liang, Dong
Format: Article
Language:English
Subjects:
antineuroinflammatory activity
Balakata baccata
flavonol glycosides
Glycosides
Kaempferol
Lipopolysaccharides
Microglial cells
Minocycline
Nitric oxide
NMR
Nuclear magnetic resonance
terpene glycosides
Two dimensional analysis
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Summary:Seven new glycosides (1 − 7) with galloyl groups and two known kaempferol glycosides (8 and 9) were obtained from the overground parts of Balakata baccata. The structures of the new compounds were determined by comprehensive spectroscopic analyses. The rarely seen allene moiety in compounds 6 and 7 were described by detailed analysis of 1D and 2D NMR data. The antineuroinflammatory effect of all the isolates was assessed through inhibiting nitric oxide (NO) production in lipopolysaccharide (LPS)-induced BV-2 microglial cells. Compounds 1, 2, 6, and 7 showed potent inhibitory activities with IC 50 values of 25.7, 17.2, 15.5 and 24.4 μM, respectively, compared with the positive control minocycline (IC 50 = 16.1 μM).
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2023.2208356