Metabolic Correction of Cerebral Radiation Syndrome in Small and Large Animals

In experiments on mice, rats, guinea pigs, and dogs, the effectiveness of metabolic correction of cerebral radiation syndrome with nicotinic and succinic acids and Essentiale was evaluated. The animals were totally exposed to 5–8 and 16–20 MeV pulsed electron flux at doses of 85–110 or 500–570 Gy or...

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Bibliographic Details
Published in:Biology bulletin of the Russian Academy of Sciences 2023-12, Vol.50 (12), p.3301-3305
Main Authors: Vasin, M. V., Ilyin, L. A., Chernov, Yu. N., Ushakov, I. B.
Format: Article
Language:English
Subjects:
Ataxia
Biochemistry
Biomedical and Life Sciences
Cell Biology
Cognitive ability
Convulsions
Decision making
Ecology
Laboratory animals
Life Sciences
Metabolism
Modification of Radiation Effects
Nicotinamide
Radiation
Seizures
Zoology
γ Radiation
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Summary:In experiments on mice, rats, guinea pigs, and dogs, the effectiveness of metabolic correction of cerebral radiation syndrome with nicotinic and succinic acids and Essentiale was evaluated. The animals were totally exposed to 5–8 and 16–20 MeV pulsed electron flux at doses of 85–110 or 500–570 Gy or to gamma irradiation at a dose of 100 Gy. The frequency and time of ataxia and convulsions, as well as the dynamics of animal death after radiation, were recorded. Nicotinic and succinic acids (500 mg/kg each) and Essentiale (20 mg/kg by nicotinamide) reduced the frequency and delayed the onset of ataxia and seizures equally in both small laboratory animals and dogs. In experiments on rats after exposure at a dose of 100 Gy under the influence of radiation and Essentiale, there was no significant change in the animal cognitive function according to the decision-making test at the first presentation of a new deposit.
ISSN:1062-3590
1608-3059
DOI:10.1134/S1062359023120233