Design, Synthesis, and Anticancer Evaluation of Chalcone Incorporated Benzothiazole-Imidazo[2,1-b]thiazole Derivatives

We have developed a new library of chalcone incorporated imidazo[2,1- b ]thiazole derivatives ( 9a – 9j ) and their structures were determined for their analytical data. Further, all were screened for their anticancer profile towards a panel of human cancer cell lines like prostate cancer (PC3), lun...

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Bibliographic Details
Published in:Russian journal of organic chemistry 2023-12, Vol.59 (Suppl 1), p.S48-S55
Main Authors: Suma, Vellanki Ragha, Prasad, Kalapala, Chandrasekhar, Choragudi, Sireesha, Reddymasu, Rao, Kuppili Ram Mohan
Format: Article
Language:English
Subjects:
Anticancer properties
Chemistry
Chemistry and Materials Science
Organic Chemistry
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Summary:We have developed a new library of chalcone incorporated imidazo[2,1- b ]thiazole derivatives ( 9a – 9j ) and their structures were determined for their analytical data. Further, all were screened for their anticancer profile towards a panel of human cancer cell lines like prostate cancer (PC3), lung cancer (A549), breast cancer (MCF-7), and ovarian cancer (A2780) by utilizing of MTT assay and etoposide used as standard reference drug. All compounds were displayed good to moderate anticancer properties on four cell lines with IC 50 values ranges from 0.012 ± 0.0076 to 21.9 ± 8.24 µM, and standard showed IC 50 values range from 1.38 ± 0.56 to 3.08 ± 0.135 µM, respectively. Amongst, five compounds 9a – 9e were exhibited more strong anticancer activities. In which, compound 9a was demonstrated excellent anticancer activity.
ISSN:1070-4280
1608-3393
DOI:10.1134/S1070428023130043