Induction of Tolerance Through Early Weaning and Oral Immunotherapy

Purpose of review The increase in IgE-mediated food allergy in the world with prevalence of egg, milk, peanut, and wheat allergies presenting and coexisting as multiple food allergies in young children. Recent findings Earlier initiation in weaning and timing of exposure of specific food allergens t...

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Bibliographic Details
Published in:Current treatment options in allergy 2018-12, Vol.5 (4), p.374-382
Main Author: Chiang, Wen Chin
Format: Article
Language:English
Subjects:
Age
Allergens
Allergology
Allergy Prevention (DY Wang
Anaphylaxis
Antigens
Asthma
Atopy
Drug dosages
Eczema
Family Medicine
Food allergies
General Practice
Immunoglobulin E
Immunotherapy
Medicine
Medicine & Public Health
Milk
Natural history
Observational studies
Rhinitis
Section Editor
Skin tests
Topical Collection on Allergy Prevention
Weaning
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Summary:Purpose of review The increase in IgE-mediated food allergy in the world with prevalence of egg, milk, peanut, and wheat allergies presenting and coexisting as multiple food allergies in young children. Recent findings Earlier initiation in weaning and timing of exposure of specific food allergens to an atopic infant appears to affect the trajectory and progression of acquiring tolerance in these children for specific foods. In this review, the allergen-specific strategies for increasing tolerance (desensitization) and hastening the resolution of food allergy (SU) are reviewed for treatment of food allergy. Summary Phenotypic complexity of the individual (eczema, asthma, rhinitis), age of the child at presentation and severity of food reactions, alongside skin test size and IgE levels can determine adopting a strategy for low-dose oral immunotherapy versus conventional oral immunotherapy to complete an immunotherapy program with the least adverse events.
ISSN:2196-3053
2196-3053
DOI:10.1007/s40521-018-0189-x