Inhibitors of bacterial cystathionine γ-lyase as antibiotic synergists Part 1. Functional derivatives of 1,3,4-oxadiazole-2-carboxylic acid: synthesis and biological activity

New structural analogs of cystathionine-γ-lyase blockers described earlier in the literature, probable synergists of antibiotics, were developed, synthesized, and studied for biological properties. According to the results of biological assays, the introduction of the 1,3,4-oxadiazole moiety into th...

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Bibliographic Details
Published in:Russian chemical bulletin 2024, Vol.73 (1), p.204-212
Main Authors: Golovina, A. V., Al’mukhametov, A. Z., Kasatkina, M. A., Belik, A. R., Cherepanova, N. D., Nawrozkij, M. B., Ivanov, R. A.
Format: Article
Language:English
Subjects:
Antibiotics
Biological activity
Biological effects
Biological properties
Carboxylic acids
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
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Inorganic Chemistry
Organic Chemistry
Oxadiazoles
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Summary:New structural analogs of cystathionine-γ-lyase blockers described earlier in the literature, probable synergists of antibiotics, were developed, synthesized, and studied for biological properties. According to the results of biological assays, the introduction of the 1,3,4-oxadiazole moiety into the molecules of test compounds deprives them of the target type of activity. In addition, the specified type of biological activity was not confirmed in one of the prototype compounds.
ISSN:1066-5285
1573-9171
DOI:10.1007/s11172-024-4132-y