Sleep Apnea and Cardiovascular Morbidity—a Perspective

Purpose of Review In this paper, we analyzed the principal mechanisms linking OSA and cardiovascular diseases, the magnitude of this association, and the effect of treatment on cardiovascular risk reduction. Furthermore, we focused on big data and genomic approaches that may expand the innovative ho...

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Bibliographic Details
Published in:Current sleep medicine reports 2018-03, Vol.4 (1), p.79-87
Main Authors: Torres, Gerard, Turino, Cecilia, Sapiña, Esther, Sánchez-de-la-Torre, Manuel, Barbé, Ferran
Format: Article
Language:English
Subjects:
Acute coronary syndromes
Big Data
Cardiac arrhythmia
Cardiology
Cardiovascular
Cardiovascular disease
Cohort analysis
Continuous positive airway pressure
Cultural differences
Data analysis
Drug dosages
Family Medicine
Gender differences
General Practice
Heart failure
Hypertension
Hypoxemia
Hypoxia
Internal Medicine
Ischemia
Longitudinal studies
Medicine
Medicine & Public Health
Metabolic Diseases
Metabolic Diseases) (D Gozal
Minority & ethnic groups
Morbidity
Mortality
Neurology
Otorhinolaryngology
Population
Psychiatry
Respiration
Risk factors
Section Editor
Sleep and 3D (Cancer
Sleep apnea
Stroke
Topical Collection on Sleep and 3D (Cancer
Transient ischemic attack
Womens health
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Summary:Purpose of Review In this paper, we analyzed the principal mechanisms linking OSA and cardiovascular diseases, the magnitude of this association, and the effect of treatment on cardiovascular risk reduction. Furthermore, we focused on big data and genomic approaches that may expand the innovative horizon aimed at personalized treatment of OSA. Recent Findings Patients with obstructive sleep apnea (OSA) are more prone to suffer from cardiovascular diseases and their complications. Arousal from sleep, changes in intrathoracic pressures, and intermittent episodes of hypoxemia and re-oxygenation trigger intermediate mechanisms that are responsible for the cardiovascular consequences of OSA. Summary The impact of OSA on cardiovascular health, such as the effect of continuous positive airway pressure (CPAP) treatment on cardiovascular risk, may vary among different patient profiles. In spite of increasing interest towards personalized therapy for OSA, observational studies and randomized clinical trials have failed to conclusively determine which OSA phenotypes may benefit most from treatment, particularly in terms of reducing cardiovascular risk.
ISSN:2198-6401
2198-6401
DOI:10.1007/s40675-018-0108-5