Facile Development of Iron-Platinum Nanoparticles to Harness Multifunctionality in Single Entity

• Published in: Acta metallurgica sinica : English letters 2016-12, Vol.29 (12), p.1098-1106
• Main Authors: Gogoi, Madhulekha, Varadarajan, Komanduri S., Patel, Anant Bahadur, Deb, Pritam
• Format: Article
• Language: English
• Subjects: Acids; Ascorbic acid; Biocompatibility; Biomedical materials; Characterization and Evaluation of Materials; Chemistry and Materials Science; Contrast agents; Corrosion and Coatings; Cytotoxicity; Decomposition; Intermetallic compounds; Iron; Iron compounds; Magnetic properties; Magnetic resonance imaging; Materials Science; Metallic Materials; Nanoparticles; Nanotechnology; Organometallic Chemistry; Physiology; Platinum; Platinum compounds; Reagents; Reducing agents; Spectroscopy/Spectrometry; Spectrum analysis; Temperature; Tribology; Uniqueness; 体功能; 开发; 生物医学应用; 磁共振成像; 简便; 线束; 铁; 铂纳米粒子
• ISSN: 1006-7191; 2194-1289
• DOI: 10.1007/s40195-016-0493-z

Engineered magnetic nanosystems exhibit attractive options for implementing unique diagnostic options and therapeutic solutions in biomedical applications. Here we report a facile, thermo-free and aqueous synthetic method to prepare ascorbic acid-stabilized iron-platinum nanoparticles. The effects of reducing agent, pH and sequence of precursor addition are investigated, and optimized reaction condition is identified to obtain a unique iron-platinum （Pt-FePt） nanosystems. The multifunctionality of the developed nanosystem has been realized by catalytic efficiency of platinum for therapeutic application and superparamagnetic property of FePt for magnetic resonance imaging contrast enhancement. Moreover, the multifunctional imaging and therapeutic activities have been achieved at physiological pH. The developed multifunctional nanoparticles are monodisperse with uniform morphology as well as stable in solution and non-toxic.