Abnormal Static and Dynamic Local Functional Connectivity in First-Episode Schizophrenia: A Resting-State fMRI Study

• Published in: IEEE transactions on neural systems and rehabilitation engineering 2024-01, Vol.32, p.1023-1033
• Main Authors: Zhou, Jie, Jiao, Xiong, Hu, Qiang, Du, Lizhao, Wang, Jijun, Sun, Junfeng
• Format: Article
• Language: English
• Subjects: Biomarkers; Brain architecture; Brain mapping; Caudate nucleus; Classification; Cognition; Cognitive ability; Coherence; Diagnostic systems; Dynamic regional phase synchrony; Fluctuations; Functional magnetic resonance imaging; Functional morphology; Homogeneity; Iron; local functional connectivity; Machine learning; Magnetic resonance imaging; Mathematical analysis; Measurement; Mental disorders; Mental task performance; Neural networks; Neuroimaging; Parahippocampal gyrus; Putamen; Regional development; regional homogeneity; resting-state fMRI; Schizophrenia; Spatial memory; Support vector machines; Synchronism; Synchronization; Time series analysis
• ISSN: 1534-4320; 1558-0210
• DOI: 10.1109/TNSRE.2024.3368697

Dynamic functional connectivity (FC) analyses have provided ample information on the disturbances of global functional brain organization in patients with schizophrenia. However, our understanding about the dynamics of local FC in never-treated first episode schizophrenia (FES) patients is still rudimentary. Dynamic Regional Phase Synchrony (DRePS), a newly developed dynamic local FC analysis method that could quantify the instantaneous phase synchronization in local spatial scale, overcomes the limitations of commonly used sliding-window methods. The current study performed a comprehensive examination on both the static and dynamic local FC alterations in FES patients (N = 74) from healthy controls (HCs, N = 41) with resting-state functional magnetic resonance imaging using DRePS, and compared the static local FC metrics derived from DRePS with those calculated from two commonly used regional homogeneity (ReHo) analysis methods that are defined based on Kendall's coefficient of concordance (KCC-ReHo) and frequency coherence (Cohe-ReHo). Symptom severities of FES patients were assessed with a set of clinical scales. Cognitive functions of FES patients and HCs were assessed with the MATRICS consensus cognitive battery. Group-level analysis revealed that compared with HCs, FES patients exhibited increased static local FC in right superior, middle temporal gyri, hippocampus, parahippocampal gyrus, putamen, and bilateral caudate nucleus. Nonetheless, the dynamic local FC metrics did not show any significant differences between the two groups. The associations between all local FC metrics and clinical characteristics manifested scores were explored using a relevance vector machine. Results showed that the Global Assessment of Functioning score highest in past year and the Brief Visuospatial Memory Test-Revised task score were statistically significantly predicted by a combination of all static and dynamic features. The diagnostic abilities of different local FC metrics and their combinations were compared by the classification performance of linear support vector machine classifiers. Results showed that the inclusion of zero crossing ratio of DRePS, one of the dynamic local FC metrics, alongside static local FC metrics improved the classification accuracy compared to using static metrics alone. These results enrich our understanding of the neurocognitive mechanisms underlying schizophrenia, and demonstrate the potential of developing diagnostic biomarker for sc