Ring‐Opening Functionalization/Cyclization Reactions of Cycloalkanols under Transition‐Metal‐Free Conditions

Cycloalkanols ring‐opening transformation is one of the most valuable and wide area of research. Among the numerous methods that have been developed, transition‐metal‐free approaches have attracted great interest from both chemists and pharmacologists. This is largely due to the advantages of being...

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Bibliographic Details
Published in:European journal of organic chemistry 2024-03, Vol.27 (9), p.n/a
Main Authors: Han, Wen‐Jun, Zhan, Jun‐Long, Yang, Fang‐Long, Liu, Lantao
Format: Article
Language:English
Subjects:
Chemical reactions
Cyclic compounds
Cyclization
Cycloalkanols
Functionalization
Ketones
Ring-opening
Transition-metal-free conditions
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Summary:Cycloalkanols ring‐opening transformation is one of the most valuable and wide area of research. Among the numerous methods that have been developed, transition‐metal‐free approaches have attracted great interest from both chemists and pharmacologists. This is largely due to the advantages of being environmentally benign, cost‐effective and operationally simple. Here we provide a comprehensive outline on recent advances in the synthesis of distally substituted ketones and cyclic compounds via ring‐opening transformation of cycloalkanols under transition‐metal‐free conditions. Cycloalkanols ring‐opening functionalization/cyclization reactions are efficient approaches for preparation of a wide range of distally substituted ketones and structurally valuable cyclic compounds, respectively. This mini‐review summarizes the recent progress in ring‐opening transformation of cycloalkanols under transition‐metal‐free conditions.
ISSN:1434-193X
1099-0690
DOI:10.1002/ejoc.202301215