Biogenic harmony of biocompatible silver nanoplatforms using chamomile extract and apigenin-7-glucoside for solid tumor therapy

This study focuses on tumor therapy using two biocompatible silver nanoplatforms of chamomile extract and its active ingredient apigenin-7-glucoside. Chamomile silver nanoparticles (Ch-AgNPs) and apigenin 7- glucoside silver nanoparticles (Ap-AgNPs) were synthesized and characterized using different...

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Bibliographic Details
Published in:Journal of radioanalytical and nuclear chemistry 2024-02, Vol.333 (2), p.705-715
Main Authors: Selim, Adli A., Abdelmonem, Islam M., Amin, Mohamed A., Essa, Basma M.
Format: Article
Language:English
Subjects:
Biocompatibility
Chemistry
Chemistry and Materials Science
Diagnostic Radiology
Glucosides
Hadrons
Heavy Ions
Inorganic Chemistry
Nanoparticles
Nuclear Chemistry
Nuclear Physics
Physical Chemistry
Radiochemical analysis
Silver
Synthesis
Tumors
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Summary:This study focuses on tumor therapy using two biocompatible silver nanoplatforms of chamomile extract and its active ingredient apigenin-7-glucoside. Chamomile silver nanoparticles (Ch-AgNPs) and apigenin 7- glucoside silver nanoparticles (Ap-AgNPs) were synthesized and characterized using different analytical techniques. On a stable nanoplatform with spherical nanoparticles in a narrow size range, both Ch-AgNP and Ap-AgNP exhibit potent cytotoxic effects against two different cell lines (HepG2 and MCF7). The synthesized NPs were radiolabeled with 131 I giving high radiochemical purity. Biodistribution studies in tumor-bearing Albino mice showed higher accumulation in tumor sites compared to normal muscle. In conclusion, after further preclinical studies, both chamomile silver nanoparticles (Ch-AgNPs) and apigenin-7-glucoside silver nanoparticles (Ap-AgNPs) can be used as potential drugs for tumor theranostics.
ISSN:0236-5731
1588-2780
DOI:10.1007/s10967-023-09323-3