On‐Chip Reconstitution of Uniformly Shear‐Sensing 3D Matrix‐Embedded Multicellular Blood Microvessel (Adv. Funct. Mater. 10/2024)

Organs‐on‐Chips In article number 2304630, Kambez H. Benam and co‐workers present the design, optimization, and validation of a robust and highly reproducible methodology for constructing centimeters‐long cross‐sectionally rounded, extracellular matrix (ECM)‐embedded, multicellular microvasculature...

Full description

Saved in:
Bibliographic Details
Published in:Advanced functional materials 2024-03, Vol.34 (10), p.n/a
Main Authors: Vo, Quoc, Carlson, Kaely A., Chiknas, Peter M., Brocker, Chad N., DaSilva, Luis, Clark, Erica, Park, Sang Ki, Ajiboye, A. Seun, Wier, Eric M., Benam, Kambez H.
Format: Article
Language:English
Subjects:
Design optimization
Endothelial cells
extracellular matrix
Mechanical properties
microvasculatures
organs‐on‐chips
organ‐on‐a‐chip
tissue engineering
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Organs‐on‐Chips In article number 2304630, Kambez H. Benam and co‐workers present the design, optimization, and validation of a robust and highly reproducible methodology for constructing centimeters‐long cross‐sectionally rounded, extracellular matrix (ECM)‐embedded, multicellular microvasculature (MV) in an Organ‐on‐a‐Chip device – a platform named “ECM MV‐Chip”. This living system allows culture of primary human‐derived, organ‐specific vascular endothelial cells and stromal cells, and fine control of ECM mechanical properties and composition.
ISSN:1616-301X
1616-3028
DOI:10.1002/adfm.202470054