Gd-doped Cerium Oxide Nanoparticles as a New MRI Contrast Agent: Analysis of Properties and Biocompatibility

The results of a study of a new nanocomposite material based on gadolinium-doped cerium oxide functionalized with folic acid as a promising material for a new MRI contrast agent are presented. As part of this work, a comprehensive analysis of their characteristics, colloidal stability, and MRI respo...

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Bibliographic Details
Published in:Physics of atomic nuclei 2023-12, Vol.86 (11), p.2551-2555
Main Authors: Kolmanovich, D. D., Mysina, E. A., Savintseva, I. V., Kozlova, T. O., Chukavin, N. N., Ivanov, V. K., Popov, A. L.
Format: Article
Language:English
Subjects:
Apoptosis
Biocompatibility
Cerium
Cerium gadolinium oxides
Cerium oxides
Contrast agents
Contrast media
Folic acid
Gadolinium
Gliomas
Magnetic resonance imaging
Nanocomposites
Particle and Nuclear Physics
Physics
Physics and Astronomy
Physics of Nanostructures
Stability analysis
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Summary:The results of a study of a new nanocomposite material based on gadolinium-doped cerium oxide functionalized with folic acid as a promising material for a new MRI contrast agent are presented. As part of this work, a comprehensive analysis of their characteristics, colloidal stability, and MRI response and a comprehensive analysis of its cytotoxicity on a U251 human glioblastoma cell culture in vitro are carried out. It is shown that this nanocomposite produces a dose-dependent cytotoxic effect on human glioblastoma cells, causing the development of intracellular oxidative stress and subsequent initiation of apoptosis. Such a nanocomposite is promising for the development of a new theranostic agent based on it, which has both MRI-contrasting properties and a pronounced redox activity, which ensures its cytotoxic effect and therapeutic activity in the cell.
ISSN:1063-7788
1562-692X
DOI:10.1134/S1063778823110212