Synthesis of quinozilinium fluoroborate salts from harmine

Molecules possessing harmine moiety are reported to exhibit marked fungicidal and bactericidal activities. In this study, various quinozilinium tetrafluoroborate salts were synthesized using acylic and cyclic oxoketene dithioacetals followed by cycloaromatization from Harmine. All of these synthesiz...

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Bibliographic Details
Published in:Carbon Letters 2021-04, Vol.31 (2), p.297-305
Main Authors: Musunuri, Sivanath, Sreenivasulu, Reddymasu, Mak, Kit-Kay, Pichika, Mallikarjuna Rao, Rao, Mandava Venkata Basaveswara
Format: Article
Language:English
Subjects:
Fungicides
NMR
Nuclear magnetic resonance
Synthesis
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Summary:Molecules possessing harmine moiety are reported to exhibit marked fungicidal and bactericidal activities. In this study, various quinozilinium tetrafluoroborate salts were synthesized using acylic and cyclic oxoketene dithioacetals followed by cycloaromatization from Harmine. All of these synthesized compounds were characterized by 1H NMR, 13C NMR, Mass and CHN analysis. This methodology would find wide usage in the preparation of indolo quinozilinium -based library of small molecules useful for medicinal chemistry and in drug discovery.Graphic abstract
ISSN:1976-4251
2233-4998
DOI:10.1007/s42823-020-00165-7