Phenotypes and Natural Evolution of Drug Hypersensitivity

s Purpose of review Drug hypersensitivity reactions (DHRs) are adverse effects that clinically resemble allergy. They belong to type B adverse drug reactions, which are dose-independent and unpredictable. Misclassification of DHR may lead to under and/or overdiagnosis, which affects the management o...

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Bibliographic Details
Published in:Current treatment options in allergy 2019-03, Vol.6 (1), p.27-41
Main Authors: Doña, Inmaculada, Salas, María, Pérez-Sánchez, Natalia Isabel, Moreno-Aguilar, Carmen, Torres, María José
Format: Article
Language:English
Subjects:
Allergies
Allergology
Anaphylaxis
Angioedema
Anti-inflammatory agents
Antibiotics
Disease
Drug Allergy (L Mayorga
Drug dosages
Edema
Enzymes
Evolution
Family Medicine
General Practice
Histamine
Hypersensitivity
Immunology
Lymphocytes
Medicine
Medicine & Public Health
Narcotics
Nonsteroidal anti-inflammatory drugs
Phenotypes
Phenotyping
Pruritus
Section Editor
T cell receptors
Terminology
Topical Collection on Drug Allergy
Urticaria
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Summary:s Purpose of review Drug hypersensitivity reactions (DHRs) are adverse effects that clinically resemble allergy. They belong to type B adverse drug reactions, which are dose-independent and unpredictable. Misclassification of DHR may lead to under and/or overdiagnosis, which affects the management of patients, leading to higher risk of suffering an allergic reaction or the use of alternative more-expensive and potentially less-effective drugs. A precise phenotype of DHR is required for a better evaluation and proper management of patients experiencing DHR. The purpose of this review is to summarise the different phenotypes of DHR basing on different criterions. Recent findings The phenotyping of DHRs is challenging as clinical presentations are heterogeneous, the underlying mechanism is poorly understood and terminology varies among different studies. Moreover, natural evolution may be different depending on the phenotype. Summary This review summarises the complexity of DHR phenotyping, which can be based on different criterions as chronology, mechanism and clinical symptoms as well as natural evolution. A precise phenotyping of DHR is needed to determine the adequate evaluation and management of patients.
ISSN:2196-3053
2196-3053
DOI:10.1007/s40521-019-0200-1