Innentitelbild: Discovery and Mechanistic Elucidation of NQO1‐Bioactivatable Small Molecules That Overcome Resistance to Degraders (Angew. Chem. 12/2024)

Multiomics‐driven elucidation of RBS‐10 as a prodrug bioactivated by the enzyme NQO1 is reported by Antoni Riera, Cristina Mayor‐Ruiz et al. in their Research Article (e202316730). RBS‐10 shows preferential cytotoxicity against cancer cells pan‐resistant to degraders.

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Bibliographic Details
Published in:Angewandte Chemie 2024-03, Vol.136 (12), p.n/a
Main Authors: Barbosa, Bárbara M. G., Sfyaki, Aikaterini, Rafael, Sergi, José‐Duran, Ferran, Pous, Joan, Sánchez‐Zarzalejo, Carolina, Perez‐Lopez, Carles, Vilanova, Mar, Cigler, Marko, Gay, Marina, Vilaseca, Marta, Winter, Georg E., Riera, Antoni, Mayor‐Ruiz, Cristina
Format: Article
Language:English
Subjects:
Biocompatibility
Biological activity
Cancer
Cytotoxicity
Online Access:Get full text
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Summary:Multiomics‐driven elucidation of RBS‐10 as a prodrug bioactivated by the enzyme NQO1 is reported by Antoni Riera, Cristina Mayor‐Ruiz et al. in their Research Article (e202316730). RBS‐10 shows preferential cytotoxicity against cancer cells pan‐resistant to degraders.
ISSN:0044-8249
1521-3757
DOI:10.1002/ange.202403450