Growth of Mesenchymal Stem Cells on Oriented Microstructured Films and Electrospun Scaffolds

The study involved the fabrication of films with different roughness and scaffolds made of poly-3-hydroxybutyrate using various methods. Chaotic and oriented scaffolds with varying fiber thickness were obtained through the electrospinning method, depending on the polymer concentration and electrospi...

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Bibliographic Details
Published in:Moscow University biological sciences bulletin 2023-12, Vol.78 (Suppl 1), p.S34-S39
Main Authors: Demianova, I. V., Akoulina, E. A., Zharkova, I. I., Voinova, V. V., Chesnokova, D. V., Hossain, A. M., Makhina, T. K., Bonartseva, G. A., Kulikouskaya, V. I., Nikalaichuk, V. V., Mukhortova, Yu. R., Pryadko, A. S., Surmeneva, M. A., Surmenev, R. A., Shaitan, K. V., Bonartsev, A. P.
Format: Article
Language:English
Subjects:
Biochemistry
Biomedical and Life Sciences
Cell Biology
Cytology
Life Sciences
Mesenchymal stem cells
Plant Sciences
Polyhydroxybutyric acid
Short Communication
Zoology
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Summary:The study involved the fabrication of films with different roughness and scaffolds made of poly-3-hydroxybutyrate using various methods. Chaotic and oriented scaffolds with varying fiber thickness were obtained through the electrospinning method, depending on the polymer concentration and electrospinning parameters. Films with different surface roughness were obtained using spin coating and self-assembly methods. It was demonstrated that the varying microstructure of the surface does not affect the growth of mesenchymal stem cells over the course of 1 week; however, it does influence the morphology of the adhered cells.
ISSN:0096-3925
1934-791X
DOI:10.3103/S0096392523700189